3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine

Base Information

• Chemical Name: 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine
• CAS No.: 1415399-44-8
• Molecular Formula: C₁₇H₂₀ClN₃S
• Molecular Weight: 333.885
• Mol file: 1415399-44-8.mol

Synonyms:3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine

Chemical Property of 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine

There total 5 articles about 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-methyl-N-phenethylcyanamide (27566-66-1) + 2-chloro-5-(methylthio)aniline hydrochloride → 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine (1415399-44-8)

Guidance literature:

In chlorobenzene; Inert atmosphere; Heating;

DOI:10.1016/j.bmc.2014.12.029

Reference yield:

N-benzylcyanamide (622-77-5) → 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine (1415399-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 18 h

2.1: chlorobenzene / Inert atmosphere; Heating

With potassium carbonate; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1016/j.bmc.2014.12.029

Reference yield:

t-butyl (2-chloro-5-(methylthio)phenyl)carbamate → 3-(2-chloro-5-(methylthio)phenyl)-1-methyl-1-phenethylguanidine (1415399-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / 6 h / Reflux

2: chlorobenzene / Inert atmosphere; Heating

With hydrogenchloride; In tetrahydrofuran; water; chlorobenzene;

DOI:10.1016/j.bmc.2014.12.029

upstream raw materials:

N-methyl-N-phenethylcyanamide

N-benzylcyanamide

benzylamine

2-chloro-5-(methylthio)benzoic acid