Technology Process of 4,4'-(cycloprop-2-ene-1,1-diyl)bis(chlorobenzene)
There total 4 articles about 4,4'-(cycloprop-2-ene-1,1-diyl)bis(chlorobenzene) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
dimethyl sulfoxide;
at 15 - 25 ℃;
for 6h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ja5032002
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium tert-butylate / hexane / 9 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
2: ethylmagnesium bromide; titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 3 h / 15 - 20 °C / Schlenk technique; Inert atmosphere
3: potassium tert-butylate / dimethyl sulfoxide / 6 h / 15 - 25 °C / Schlenk technique; Inert atmosphere
With
titanium(IV) isopropylate; ethylmagnesium bromide; potassium tert-butylate;
In
tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide;
DOI:10.1021/ja5032002
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere
1.2: Inert atmosphere
2.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane; water / 20 °C
3.1: titanium(IV) chloride tetrahydrofuran complex; ethylmagnesium bromide / tetrahydrofuran; 2-methyltetrahydrofuran / 0.17 h / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
With
titanium(IV) chloride tetrahydrofuran complex; ethylmagnesium bromide; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.orglett.1c01775
