4-(6-Methoxypyridin-2-yl)benzotrifluoride

Base Information

• Chemical Name: 4-(6-Methoxypyridin-2-yl)benzotrifluoride
• CAS No.: 1202026-99-0
• Molecular Formula: C₁₃H₁₀F₃NO
• Molecular Weight: 253.224
• Mol file: 1202026-99-0.mol

Synonyms:6-methoxy-2-{4-(trifluoromethyl)phenyl}pyridine

Chemical Property of 4-(6-Methoxypyridin-2-yl)benzotrifluoride

Chemical Property:

• Boiling Point: 283.0±35.0 °C(Predicted)
• PKA: 2.00±0.25(Predicted)
• Density: 1.232±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine is a synthetic reagent used in the preparation of substituted pyrazinone, pyrimidinone and pyridone compounds.

Technology Process of 4-(6-Methoxypyridin-2-yl)benzotrifluoride

There total 5 articles about 4-(6-Methoxypyridin-2-yl)benzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Iodobenzotrifluoride (455-13-0) + (6-methoxy-2-pyridyl)magnesium bromide (1226769-58-9) → 6-methoxy-2-{4-(trifluoromethyl)phenyl}pyridine (1202026-99-0)

Guidance literature:

4-Iodobenzotrifluoride; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(1-adamantyl)phosphine oxide; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

(6-methoxy-2-pyridyl)magnesium bromide; In tetrahydrofuran; at 60 ℃; for 20h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201000032

Reference yield: 87.0%

(6-methoxy-2-pyridyl)magnesium bromide (1226769-58-9) + p-trifluoromethylphenyl bromide (402-43-7) → 6-methoxy-2-{4-(trifluoromethyl)phenyl}pyridine (1202026-99-0)

Guidance literature:

p-trifluoromethylphenyl bromide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(1-adamantyl)phosphine oxide; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

(6-methoxy-2-pyridyl)magnesium bromide; In tetrahydrofuran; at 60 ℃; for 20h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201000032

Reference yield: 79.0%

p-trifluoromethylphenyl bromide (402-43-7) + 2-methoxy-6-(tri-n-butylstannyl)pyridine (164014-94-2) → 6-methoxy-2-{4-(trifluoromethyl)phenyl}pyridine (1202026-99-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; lithium chloride; In tetrahydrofuran; at 70 ℃; for 18h;

DOI:10.1055/s-0034-1378331

upstream raw materials:

p-trifluoromethylphenyl bromide

4-Iodobenzotrifluoride

(6-methoxy-2-pyridyl)magnesium bromide

2-methoxy-6-(tri-n-butylstannyl)pyridine

Downstream raw materials:

6-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one