1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole

Base Information

• Chemical Name: 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole
• CAS No.: 302919-27-3
• Molecular Formula: C₂₁H₂₂ClN₃O₄S
• Molecular Weight: 447.942

Synonyms:1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole

Chemical Property of 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole

Chemical Property:

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Technology Process of 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole

There total 3 articles about 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]-1-(4'-chlorophenylamino)-4-methyl-5-phenyl-1H-imidazole (302919-22-8) → 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole (302919-27-3)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1135/cccc20001145

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) → 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole (302919-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / NaH / dimethylformamide

2: 85 percent / NaOMe / methanol / 20 °C

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1081/NCN-120021429

Reference yield:

1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione (191349-41-4) → 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-2-(β-D-ribofuranosyl)sulfanyl-1H-imidazole (302919-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / NaH / dimethylformamide

2: 85 percent / NaOMe / methanol / 20 °C

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1081/NCN-120021429

upstream raw materials:

2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]-1-(4'-chlorophenylamino)-4-methyl-5-phenyl-1H-imidazole

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione

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