(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Base Information

Chemical Name:(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide
CAS No.:885022-40-2
Molecular Formula:C₃₀H₄₉NO₄
Molecular Weight:487.723
Hs Code.:

Synonyms:(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Suppliers and Price of (Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

There total 4 articles about (Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-(ethoxycarbonyl)phenylalaninol hydrochloride

: 112-80-1,2027-47-6
cis-Octadecenoic acid

: 885022-40-2
(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Guidance literature:: cis-Octadecenoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.25h;

(R)-4-(ethoxycarbonyl)phenylalaninol hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm051226l

Reference yield:

: 210962-92-8
tert-butyl [(2R)-1-hydroxy-3-(4-iodophenyl)propan-2-yl]carbamate

: 885022-40-2
(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 53 percent / Pd(OAc)2; PPh₃; Et₃N / dimethylformamide / 12 h / 80 °C

2.1: HCl / ethyl acetate / 5 h / 20 °C

3.1: HOBt; EDC / dimethylformamide / 1.25 h / 0 - 20 °C

3.2: Et₃N / dimethylformamide / 12 h / 20 °C

With hydrogenchloride; palladium diacetate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm051226l

Reference yield:

: 885022-32-2
(R)-N-tert-butoxycarbonyl-4-(ethoxycarbonyl)phenylalaninol

: 885022-40-2
(Z)-N-{(1R)-2-hydroxy-1-[[4-(ethoxycarbonyl)phenyl]methyl]ethyl}-9-octadecenamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / ethyl acetate / 5 h / 20 °C

2.1: HOBt; EDC / dimethylformamide / 1.25 h / 0 - 20 °C

2.2: Et₃N / dimethylformamide / 12 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm051226l