2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

Base Information

Chemical Name:2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate
CAS No.:873301-64-5
Molecular Formula:C₂₁H₂₁ClFN₃O₅
Molecular Weight:449.866
Hs Code.:

Synonyms:2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

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Chemical Property of 2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

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Technology Process of 2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

There total 1 articles about 2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 26923-87-5
2-acetoxyethyl-2'-tosyloxyethyl ether

: 193001-59-1
4-(4-chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

: 873301-64-5
2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1016/j.bmcl.2005.09.036

Reference yield: 65.0%

: 873301-64-5
2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

: 873301-65-6
2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethanol

Guidance literature:: With ammonium hydroxide; In methanol; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2005.09.036

Reference yield:

: 873301-64-5
2-{2-[4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy]ethoxy}ethyl acetate

: 4-Azido-N-{(S)-1-(2-{2-[4-(4-chloro-2-fluoro-phenylamino)-6-methoxy-quinazolin-7-yloxy]-ethoxy}-ethylcarbamoyl)-5-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-pentyl}-2,3,5,6-tetrafluoro-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / aq. NH₃ / methanol / 12 h / 20 °C

2: 99 percent / NEt₃ / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

3: 67 percent / NaN₃ / ethanol; H₂O / 3 h / 80 °C

4: 95 percent / H₂ / Pd(OH)2/C / methanol / 1 h

5: 98 percent / dimethylformamide / 12 h / 20 °C

With ammonium hydroxide; sodium azide; hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.036