(dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate

Base Information

• Chemical Name: (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate
• CAS No.: 1332458-72-6
• Molecular Formula: C₂₃H₂₅N₂O₈P
• Molecular Weight: 488.434
• Mol file: 1332458-72-6.mol

Synonyms:(dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate

Chemical Property of (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate

There total 2 articles about (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

dimethyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate (100134-07-4) + 2-(4',6'-dimethoxypyrimidine-2'-yl)oxy-benzoic acid (110284-78-1) → (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate (1332458-72-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃;

DOI:10.1080/10426507.2010.511512

Reference yield:

4-methyl-benzaldehyde (104-87-0) → (dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate (1332458-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum oxide; potassium fluoride / 0.5 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 25 °C

With dmap; aluminum oxide; potassium fluoride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1080/10426507.2010.511512

Reference yield:

(dimethoxyphosphoryl)(p-tolyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate (1332458-72-6) → C21H21N2O8P

Guidance literature:

With hydrogenchloride; water;

DOI:10.1080/10426507.2010.511512

upstream raw materials:

dimethyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate

2-(4',6'-dimethoxypyrimidine-2'-yl)oxy-benzoic acid

4-methyl-benzaldehyde