2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

Base Information

Chemical Name:2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid
CAS No.:1292211-44-9
Molecular Formula:C₂HF₃O₂*C₂₅H₂₉FN₆O₄
Molecular Weight:610.565
Hs Code.:

Synonyms:2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

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Chemical Property of 2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

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Technology Process of 2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

There total 7 articles about 2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292211-42-7
2-((8-(benzyloxy)-5-(4-(4-(tert-butoxycarbonylamino)butyl)piperazin-1-yl)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid

: 76-05-1
trifluoroacetic acid

: 1292211-44-9
2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1292211-41-6
ethyl 2?((8?(benzyloxy)?5?(4?(4?(tert-butoxycarbonylamino)butyl)piperazin?1?yl)?1,6?naphthyridine?7?carboxamido)methyl)?5?fluorobenzoate

: 1292211-44-9
2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 20 °C

1.2: pH 6 - 7

2.1: dichloromethane / 1 h / 0 - 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1292211-00-7
methyl 8-(benzyloxy)-5-bromo-1,6-naphthyridine-7-carboxylate

: 1292211-44-9
2-((5-(4-(4-aminobutyl)piperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.08 h / 20 °C

1.2: 12 h / 110 °C

2.1: potassium carbonate / ISOPROPYLAMIDE / 12 h / 20 °C

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 6

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

4.2: 20 °C

5.1: water; lithium hydroxide / water; tetrahydrofuran / 24 h / 20 °C

5.2: pH 6 - 7

6.1: dichloromethane / 1 h / 0 - 20 °C

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; water;