(Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

Base Information

Chemical Name:(Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol
CAS No.:1542264-02-7
Molecular Formula:C₂₇H₃₁FO₂Si
Molecular Weight:434.626
Hs Code.:

Synonyms:(Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

Suppliers and Price of (Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

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Technology Process of (Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

There total 2 articles about (Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1542264-15-2
1-bromo-3-(tert-butyldiphenylsilyloxy)-1,1-difluoropropane

: 104-87-0
4-methyl-benzaldehyde

: 1542264-02-7
(Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

Guidance literature:: With chromium dichloride; lithium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; stereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0035-1560390

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1542264-02-7
(Z)-4-(tert-butyldiphenylsilyloxy)-2-fluoro-1-(4-methylphenyl)-2-buten-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane; hexane / 5 h / -78 - 0 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: chromium dichloride; lithium iodide / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With chromium dichloride; diisobutylaluminium hydride; lithium iodide; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc47219a