(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

Base Information

Chemical Name:(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one
CAS No.:90211-62-4
Molecular Formula:C₅₀H₄₃N₄O₆PS₂
Molecular Weight:891.02
Hs Code.:

(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

Synonyms:(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

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Chemical Property of (3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

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Technology Process of (3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

There total 10 articles about (3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90211-56-6
(3R,4R)-4-{(1R)-3-diazo-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

: 29490-19-5
2-mercapto-5-methyl-1,3,4-thiadiazole

: 90211-62-4
(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

Guidance literature:: With dirhodium tetraacetate; In ethyl acetate; at 60 ℃; for 0.666667h;
DOI:10.3987/COM-90-5345

Reference yield:

: 90211-54-4
(3R,4R)-4-{(1R)-1-carboxyethoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

: 90211-62-4
(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methylmorpholine / CH₂Cl₂ / 0.5 h / -10 °C

3: rhodium(II) acetate dimer / ethyl acetate / 0.67 h / 60 °C

With 4-methyl-morpholine; dirhodium tetraacetate; In dichloromethane; ethyl acetate;
DOI:10.3987/COM-90-5345

Reference yield:

: 90211-53-3
(3R,4R)-4-{(1R)-1-ethoxycarbonylethoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

: 90211-62-4
(3R,4R)-4-{(1R)-3-(2-methyl-1,3,4-thiadiazole-5-yl)thio-2-oxo-1-methylpropoxy}-3-benzamido-1-(1-diphenylmethoxycarbonyl-1-triphenylphosphoranylidenemethyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂O, NaOH / acetone / 1.5 h / 5 °C

2: 4-methylmorpholine / CH₂Cl₂ / 0.5 h / -10 °C

4: rhodium(II) acetate dimer / ethyl acetate / 0.67 h / 60 °C

With 4-methyl-morpholine; dirhodium tetraacetate; sodium hydroxide; water; In dichloromethane; ethyl acetate; acetone;
DOI:10.3987/COM-90-5345