(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

Base Information

Chemical Name:(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate
CAS No.:171779-40-1
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

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Chemical Property of (S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

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Technology Process of (S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

There total 2 articles about (S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 171779-39-8
(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-oxo-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

: (S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-endo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

: 171779-40-1
(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -4 ℃; for 3h;
DOI:10.1021/jo00129a053

Reference yield:

: 8-Benzyl-2-oxo-8-aza-bicyclo[3.2.1]oct-3-ene-6-carboxylic acid (S)-1-methoxycarbonyl-ethyl ester

: 171779-40-1
(S)-1-(Methoxycarbonyl)etyl 8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 15 h / 735.5 Torr / Ambient temperature

2: 61.8 percent / LiAl(OtBu)3H / tetrahydrofuran / 3 h / -4 °C

With hydrogen; lithium tri-t-butoxyaluminum hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00129a053