(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

Base Information

Chemical Name:(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide
CAS No.:1246566-97-1
Molecular Formula:C₃₁H₄₄F₃NO₂Si
Molecular Weight:547.777
Hs Code.:

Synonyms:(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

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Chemical Property of (E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

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Technology Process of (E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

There total 5 articles about (E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (E)-1,6-diphenylhex-3-en-2-yl-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetimidate

: 1246566-97-1
(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/asia.201000386

Reference yield:

: 33046-84-3,112087-56-6,37868-70-5
(2E)-5-phenyl-2-pentenal

: 1246566-97-1
(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / Inert atmosphere; Reflux

1.2: 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II) / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/asia.201000386

Reference yield:

: 1246566-71-1
(E)-1,6-diphenylhex-3-en-2-ol

: 1246566-97-1
(E)-N-(1,6-diphenylhex-4-en-3-yl)-2,2,2-trifluoro-N-(2-((triisopropylsilyl)oxy)ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: dichloro bis(acetonitrile) palladium(II) / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/asia.201000386