6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Base Information

Chemical Name:6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole
CAS No.:1085454-06-3
Molecular Formula:C₂₅H₃₁BrN₄OSi
Molecular Weight:511.537
Hs Code.:

Synonyms:6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

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Chemical Property of 6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

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Technology Process of 6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

There total 6 articles about 6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1085451-26-8
6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1H-benzimidazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: C₂₅H₃₁BrN₄OSi

: 1085454-06-3
6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1085454-04-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbaldehyde

: 1085454-06-3
6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogen sulfite / N,N-dimethyl-formamide / 5 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With sodium hydrogen sulfite; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1085454-02-9
[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]methanol

: 1085454-06-3
6-bromo-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C

1.2: 0.33 h / 0 °C

2.1: sodium hydrogen sulfite / N,N-dimethyl-formamide / 5 h / 110 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With sodium hydrogen sulfite; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;