Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

Base Information

• Chemical Name: Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester
• CAS No.: 183240-06-4
• Molecular Formula: C₅₀H₅₇NO₁₅
• Molecular Weight: 912

Synonyms:Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

Chemical Property of Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

There total 17 articles about Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-(4-methoxy-benzyloxy)-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester (183240-05-3) → Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester (183240-06-4)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1002/jlac.199619961016

Reference yield: 86.0%

Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-(2-chloro-acetoxy)-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester (183240-07-5) → Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester (183240-06-4)

Guidance literature:

With thiourea; In methanol; for 312h; Ambient temperature;

DOI:10.1002/jlac.199619961016

Reference yield: 35.0%

Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-2-ethylsulfanyl-5-hydroxy-6-methyl-tetrahydro-pyran-3-yl ester (183239-97-6) → Benzoic acid (1R,3S,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester + Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-hydroxy-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.03,8]nonadec-16-yl ester (183240-06-4)

Guidance literature:

With N-iodo-succinimide; 3 A molecular sieve; In acetonitrile; at 0 ℃; for 21h;

DOI:10.1002/jlac.199619961016

upstream raw materials:

Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-2-ethylsulfanyl-5-hydroxy-6-methyl-tetrahydro-pyran-3-yl ester

Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-(2-chloro-acetoxy)-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

Benzoic acid (1R,3R,5S,6S,7R,8R,15S,16R,17R,19R)-7-benzyloxy-17-(5-benzyloxycarbonylamino-pentyloxy)-19-benzyloxymethyl-6-(4-methoxy-benzyloxy)-5-methyl-10,13-dioxo-2,4,9,14,18-pentaoxa-tricyclo[13.4.0.0^3,8]nonadec-16-yl ester

benzyl bromide

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