Synonyms:(Ethynediyl)copper;Copper carbide (Cu(C2)); Ethyne, copper(2+) deriv.
99% *data from raw suppliers
The study presents a copper-catalyzed one-pot synthesis of alkynyl imidates and alkynyl thioimidates through a coupling reaction involving terminal alkynes, trichloroimidates generated in situ from trichloroacetonitrile and benzyl alcohols or thiols. The key chemicals include phenylacetylene as a model terminal alkyne, trichloroacetonitrile as a precursor for trichloroimidates, and benzyl alcohol or thiol as the source of the imidate or thioimidate group. Copper iodide (CuI) acts as the catalyst, and triethylamine (Et3N) is used as a base. The reaction is optimized in acetonitrile at room temperature, yielding the desired products in good yields. The mechanism involves the formation of a copper acetylide intermediate, which reacts with the trichloroimidates to form a tetrahedral intermediate, followed by the elimination of CuCCl3 to produce the final products. This method offers a versatile and efficient route for synthesizing functionalized alkynes with readily available starting materials and catalysts.
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