N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

Base Information

Chemical Name:N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide
CAS No.:853018-47-0
Molecular Formula:C₂₆H₃₂N₄O₃
Molecular Weight:448.565
Hs Code.:

Synonyms:N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

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Chemical Property of N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

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Technology Process of N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

There total 5 articles about N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] trifluoroacetate

: 109-90-0
ethyl isocyanate

: 853018-47-0
N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

Guidance literature:: 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] trifluoroacetate; ethyl isocyanate; In dichloromethane;

With ammonia; In methanol; chloroform;

Reference yield:

: 66-83-1
5-methoxytryptamine hydrochloride

: 853018-47-0
N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / 100 °C

1.2: 72 h

2.1: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

4.1: dichloromethane

With potassium carbonate; acetic acid; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 853020-88-9,853020-89-0,853020-91-4
1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853018-47-0
N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

4: dichloromethane

With hydrogen; potassium carbonate; palladium dihydroxide; In methanol; dichloromethane; water; acetonitrile;