4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

Base Information

Chemical Name:4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride
CAS No.:1290053-79-0
Molecular Formula:C₂₂H₂₇N₃O₅*ClH
Molecular Weight:449.934
Hs Code.:

Synonyms:4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

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Chemical Property of 4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

Chemical Property:

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Technology Process of 4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

There total 8 articles about 4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1290056-67-5
tert-butyl 4-((4-(3-((3aR,6aR)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)-3-oxopropoxy)benzyl)carbamoyl)benzylcarbamate

: 1290053-79-0
4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; water; In methanol; at 0 - 20 ℃; for 4h;

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1290053-79-0
4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 0 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 20 °C

5.1: hydrogenchloride; water / methanol / 4 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 1290053-79-0
4-(aminomethyl)-N-(4-(3-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropoxy)benzyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 0 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 20 °C

4.1: hydrogenchloride; water / methanol / 4 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;