2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Base Information

Chemical Name:2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
CAS No.:1589071-19-1
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

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Chemical Property of 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Chemical Property:

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Technology Process of 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

There total 3 articles about 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 343778-74-5
3-(1-methyl-1H-indol-3-yl)-3-oxopropanenitrile

: 1589071-19-1
2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; Cooling with ice;
DOI:10.1016/j.bmcl.2014.03.011

Reference yield:

: 120-72-9
indole

: 1589071-19-1
2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate

2: acetic anhydride / 50 - 85 °C

3: potassium hydroxide / ethanol / 20 °C / Cooling with ice

With acetic anhydride; potassium carbonate; potassium hydroxide; In ethanol; 2: |Friedel-Crafts Acylation / 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.03.011

Reference yield:

: 603-76-9
1-methylindole

: 1589071-19-1
2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 50 - 85 °C

2: potassium hydroxide / ethanol / 20 °C / Cooling with ice

With acetic anhydride; potassium hydroxide; In ethanol; 1: |Friedel-Crafts Acylation / 2: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.03.011