2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

Base Information

Chemical Name:2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid
CAS No.:1346223-07-1
Molecular Formula:C₂₀H₁₈FNO₄S
Molecular Weight:387.432
Hs Code.:

Synonyms:2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

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Chemical Property of 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

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Technology Process of 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

There total 5 articles about 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 959632-81-6
ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate

: 1346223-07-1
2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 40 ℃; for 3h;

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 1346223-07-1
2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium peroxomonosulfate / methanol; water / 20 °C

2: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

3: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere

4: triethylsilane; trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

5: water; sodium hydroxide / methanol / 1.5 h / Reflux

With triethylsilane; potassium peroxomonosulfate; water; titanium tetrachloride; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm200715n

Reference yield:

: ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

: 1346223-07-1
2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

2: water; sodium hydroxide / methanol / 1.5 h / Reflux

With triethylsilane; water; trifluoroacetic acid; sodium hydroxide; In methanol;
DOI:10.1021/jm200715n