(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Base Information

Chemical Name:(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine
CAS No.:1613582-66-3
Molecular Formula:C₂₇H₃₁NO₂S₂
Molecular Weight:465.681
Hs Code.:

Synonyms:(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Suppliers and Price of (2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Chemical Property:

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Technology Process of (2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

There total 4 articles about (2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 14204-27-4
N-phenylthiophthalimide

: 1613582-53-8
(E)-4-methyl-N-(8-phenyloct-5-en-1-yl)benzenesulfonamide

: 1613582-66-3
(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Guidance literature:: With methanesulfonic acid; (S)-4-(diisopropylamino)-3,5-dimethyl-4,5-dihydro-3H-dinaphtho[2,1-d:1’,2’-f][1,3,2]diazaphosphepine-4-selenide; In dichloromethane; at 0 ℃; for 48h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/ja5046296

Reference yield: 91.0%

: 14204-27-4
N-phenylthiophthalimide

: 4-methyl-N-(8-phenyloct-5-en-1-yl)benzenesulfonamide

: 1613582-66-3
(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Guidance literature:: With methanesulfonic acid; (S)-4-(diisopropylamino)-3,5-dimethyl-4,5-dihydro-3H-dinaphtho[2,1-d:1’,2’-f][1,3,2]diazaphosphepine-4-selenide; In dichloromethane; at 0 ℃; for 48h; enantioselective reaction;
DOI:10.15227/orgsyn.096.0400

Reference yield:

: 1027021-29-9
Methanesulfonic acid (E)-7-phenyl-hept-4-enyl ester

: 1613582-66-3
(2S,7R)-N-(4-toluenesulfonyl)-2-(3-phenyl-1-(phenylthio)propyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere; Schlenk technique

2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

2.2: 4 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

3.1: methanesulfonic acid; (S)-4-(diisopropylamino)-3,5-dimethyl-4,5-dihydro-3H-dinaphtho[2,1-d:1’,2’-f][1,3,2]diazaphosphepine-4-selenide / dichloromethane / 48 h / 0 °C / Inert atmosphere; Schlenk technique

With lithium aluminium tetrahydride; methanesulfonic acid; (S)-4-(diisopropylamino)-3,5-dimethyl-4,5-dihydro-3H-dinaphtho[2,1-d:1’,2’-f][1,3,2]diazaphosphepine-4-selenide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja5046296