C₂₈H₃₀FN₃O₃

Base Information

• Chemical Name: C₂₈H₃₀FN₃O₃
• CAS No.: 1367126-93-9
• Molecular Formula: C₂₈H₃₀FN₃O₃
• Molecular Weight: 475.563
• Mol file: 1367126-93-9.mol

Synonyms:C₂₈H₃₀FN₃O₃

Chemical Property of C₂₈H₃₀FN₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₀FN₃O₃

There total 10 articles about C₂₈H₃₀FN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H27ClFN3O3 (1367126-91-7) + pinacol vinylboronate (75927-49-0) → C28H30FN3O3 (1367126-93-9)

Guidance literature:

With tetrabutyl ammonium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; at 80 ℃; for 5h;

Reference yield:

4-Fluorophenol (371-41-5) → C28H30FN3O3 (1367126-93-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C

6.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 5 h / 80 °C

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → C28H30FN3O3 (1367126-93-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C

6.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 5 h / 80 °C

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

upstream raw materials:

4-Fluorophenol

4-Fluoronitrobenzene

4-(4-fluorophenoxy)aniline

C₂₆H₂₇ClFN₃O₃

Downstream raw materials:

C₂₈H₃₂FN₃O₅