ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate
CAS No.:1147864-01-4
Molecular Formula:C₁₈H₂₄NO₆P
Molecular Weight:381.365
Hs Code.:

Synonyms:ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

There total 5 articles about ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 945483-73-8
(1-bromo-2-(hydroxyimino)propyl)phosphonic acid diethyl ester

: 42367-54-4
(E)-ethyl 3-phenyl-3-(pyrrolidin-1-yl)acrylate

: 1147864-01-4
ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; regioselective reaction;
DOI:10.1021/jo900489j

Reference yield: 94.0%

: 945483-94-3
C₇H₁₄NO₄P

: 53256-23-8
ethyl β-(1-pyrrolidinyl)cinnamate

: 1147864-01-4
ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1080/10426507.2010.522632

Reference yield:

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 1147864-01-4
ethyl 4-(diethoxyphosphoryl)-1-hydroxy-5-methyl-2-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 1 h / 20 °C

1.2: 0 °C

2.1: hydroxylamine hydrochloride; triethylamine / methanol / 20 °C

3.1: triethylamine / dichloromethane / Cooling with ice

4.1: dichloromethane / 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium ethanolate; triethylamine; In methanol; ethanol; dichloromethane; 4.1: Michael condensation;
DOI:10.1080/10426507.2010.522632