Technology Process of 2-(5-(2-hydroxyethoxy)-6-(4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate
There total 8 articles about 2-(5-(2-hydroxyethoxy)-6-(4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonic acid;
In
methanol; dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 20 h / 60 °C / Inert atmosphere
2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere
4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 20 h / 120 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
6.1: methanesulfonic acid / dichloromethane; methanol / 1 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); methanesulfonic acid; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.2: 20 h / 60 °C / Inert atmosphere
3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); sodium hydrogensulfite / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 20 h / 120 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7.1: methanesulfonic acid / dichloromethane; methanol / 1 h / 20 °C
With
ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium(0); methanesulfonic acid; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
