benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

Base Information

Chemical Name:benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate
CAS No.:1629189-89-4
Molecular Formula:C₂₄H₂₃NO₄
Molecular Weight:389.451
Hs Code.:

Synonyms:benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

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Technology Process of benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

There total 3 articles about benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1629189-86-1
(E)-benzyl 3-(1-(2-iodo-4,5-dimethoxyphenylethyl)-1H-pyrrol-2-yl)acrylate

: 1629189-89-4
benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

Guidance literature:: With tetrabutylammonium acetate; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; at 60 ℃; for 2h;
DOI:10.1002/adsc.201400075

Reference yield:

: 1432487-62-1
1-(2-iodo-4,5-dimethoxyphenethyl)-1H-pyrrole-2-carbaldehyde

: 1629189-89-4
benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 96 h / Reflux

2: palladium diacetate; triphenylphosphine; tetrabutylammonium acetate / dimethyl sulfoxide / 2 h / 60 °C

With tetrabutylammonium acetate; palladium diacetate; triphenylphosphine; In dichloromethane; dimethyl sulfoxide; 2: |Heck Reaction;
DOI:10.1002/adsc.201400075

Reference yield:

: 15097-38-8
(carbobenzyloxymethylene)triphenylphosphorane

: 1629189-89-4
benzyl 3-(2E)-(8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 96 h / Reflux

2: palladium diacetate; triphenylphosphine; tetrabutylammonium acetate / dimethyl sulfoxide / 2 h / 60 °C

With tetrabutylammonium acetate; palladium diacetate; triphenylphosphine; In dichloromethane; dimethyl sulfoxide; 2: |Heck Reaction;
DOI:10.1002/adsc.201400075