methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate
CAS No.:1390640-83-1
Molecular Formula:C₁₂H₈ClF₂N₃O₂
Molecular Weight:299.664
Hs Code.:

Synonyms:methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

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Chemical Property of methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

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Technology Process of methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

There total 1 articles about methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 944129-00-4
methyl 6-amino-2-chloropyrimidine-4-carboxylate

: 1116681-98-1
2-(4-chloro-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1390640-83-1
methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

Guidance literature:: With cesium fluoride; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In water; acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

Reference yield: 79.0%

: 1390640-83-1
methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

: 1390640-84-2
methyl 6-amino-5-bromo-2-(4-chloro-2,3-difluorophenyl)pyrimidine-4-carboxylate

Guidance literature:: With bromine; potassium acetate; acetic acid; at 23 ℃; for 2h;

Reference yield:

: 1390640-83-1
methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate

: 1390640-70-6
(E)-6-amino-2-(4-chloro-2,3-difluorophenyl)-5-(2-(trimethylsilyl)vinyl)pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; potassium acetate; acetic acid / 2 h / 23 °C

2.1: cesium fluoride / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.25 h / 150 °C / Microwave irradiation

3.1: sodium hydroxide / water; methanol / 3 h / 20 - 23 °C

3.2: pH ~ 4

With bromine; potassium acetate; acetic acid; cesium fluoride; sodium hydroxide; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In methanol; water; acetonitrile;