(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

Base Information

Chemical Name:(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline
CAS No.:1263193-47-0
Molecular Formula:C₂₃H₁₉N₅
Molecular Weight:365.437
Hs Code.:

Synonyms:(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

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Chemical Property of (E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

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Technology Process of (E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

There total 5 articles about (E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123511-51-3
1-methyl-4-phenyl-1H-imidazole-2-carbaldehyde

: 1263193-38-9
((2-methylpyrazolo[1,5-c]quinazolin-5-yl)methyl)triphenylphosphonium chloride

: 1263193-47-0
(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

Guidance literature:: ((2-methylpyrazolo[1,5-c]quinazolin-5-yl)methyl)triphenylphosphonium chloride; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -5 ℃; for 0.5h;

1-methyl-4-phenyl-1H-imidazole-2-carbaldehyde; In N,N-dimethyl-formamide; mineral oil; at -5 - 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2010.10.038

Reference yield:

: 911719-02-3
methyl 1-methyl-4-phenyl-1H-imidazole-2-carboxylate

: 1263193-47-0
(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

2.1: Dess-Martin periodane / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.01 h / -5 °C

3.2: 1.5 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2-carbomethoxy-4⁽⁵⁾-phenylimidazole

: 1263193-47-0
(E)-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[1,5-c]quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

3.1: Dess-Martin periodane / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.01 h / -5 °C

4.2: 1.5 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;