3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Base Information

Chemical Name:3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne
CAS No.:1431619-82-7
Molecular Formula:C₅₀H₇₄O₂Si₂
Molecular Weight:763.307
Hs Code.:

Synonyms:3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Suppliers and Price of 3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

There total 10 articles about 3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: (3R)-3-[(tert-butyldiphenylsilyl)oxy]-1-ethynyl-2-methyl-4-methylene-cyclohexene

: 530147-04-7
(6R)-6-[(1R,3aR,7aR)-4-(trifluoromethanesulfonyloxy)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-yl]-2-methyl-2-(triethylsilyloxy)heptane

: 1431619-82-7
3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Guidance literature:: With copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 13944-81-5
7-methyl-1,4-dioxa-spiro[4.5]decan-8-ol

: 1431619-82-7
3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 3 h / 60 °C

2.1: iron(III) chloride hexahydrate / dichloromethane / 1.5 h / 20 °C

3.1: L-proline; Nitrosobenzene / chloroform / 26 h / 4 - 20 °C

4.1: silver nitrate / N,N-dimethyl-formamide / 30 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 0 - 20 °C

5.2: 4 h / -78 - 20 °C

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - -40 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

8.2: 0.75 h / -78 - 0 °C

9.1: Martins sulfurane / tetrachloromethane / 6 h / 20 °C / Inert atmosphere

9.2: 19 h / 20 °C / Inert atmosphere

10.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; Martins sulfurane; iron(III) chloride hexahydrate; diisobutylaluminium hydride; Dess-Martin periodane; silver nitrate; diethylamine; Nitrosobenzene; L-proline; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 5.2: |Wittig Olefination;

Reference yield:

: trans-7-methyl-8-pivaloyloxy-1,4-dioxa-spiro[4.5]decane

: 1431619-82-7
3-desoxy-1α-[(tert-butyldiphenylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

Guidance literature:: Multi-step reaction with 9 steps

1.1: iron(III) chloride hexahydrate / dichloromethane / 1.5 h / 20 °C

2.1: L-proline; Nitrosobenzene / chloroform / 26 h / 4 - 20 °C

3.1: silver nitrate / N,N-dimethyl-formamide / 30 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 0 - 20 °C

4.2: 4 h / -78 - 20 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - -40 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

7.2: 0.75 h / -78 - 0 °C

8.1: Martins sulfurane / tetrachloromethane / 6 h / 20 °C / Inert atmosphere

8.2: 19 h / 20 °C / Inert atmosphere

9.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; Martins sulfurane; iron(III) chloride hexahydrate; diisobutylaluminium hydride; Dess-Martin periodane; silver nitrate; diethylamine; Nitrosobenzene; L-proline; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 4.2: |Wittig Olefination;