methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate

Base Information

• Chemical Name: methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate
• CAS No.: 886539-46-4
• Molecular Formula: C₂₈H₃₃N₃O₆
• Molecular Weight: 507.587

Synonyms:methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate

Chemical Property of methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate

There total 3 articles about methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}amino-3-methylbutanoate (886539-45-3) + n-valeryl chloride (638-29-9) → methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate (886539-46-4)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1080/00397910500447066

Reference yield:

L-valine methylester hydrochloride (6306-52-1) → methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate (886539-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / triethylamine; 4-(dimethylamino)pyridine; KI / acetonitrile; CH₂Cl₂ / 36 h / 20 °C

2: 88 percent / pyridine / 20 °C

With pyridine; dmap; triethylamine; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1080/00397910500447066

Reference yield:

methyl 2-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]benzoate (593287-06-0) → methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}(pentanoyl)amino-3-methylbutanoate (886539-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / triethylamine; 4-(dimethylamino)pyridine; KI / acetonitrile; CH₂Cl₂ / 36 h / 20 °C

2: 88 percent / pyridine / 20 °C

With pyridine; dmap; triethylamine; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1080/00397910500447066

upstream raw materials:

methyl (S)-2-{[4-[5-(2-carbomethoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl}amino-3-methylbutanoate

n-valeryl chloride

L-valine methylester hydrochloride

methyl 2-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]benzoate

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