3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

Base Information

Chemical Name:3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester
CAS No.:155143-19-4
Molecular Formula:C₃₅H₃₃ClN₂O₄S
Molecular Weight:613.177
Hs Code.:

Synonyms:3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

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Chemical Property of 3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

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Technology Process of 3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

There total 5 articles about 3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 161446-67-9,161447-72-9,161447-75-2
<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methanol

: 155143-19-4
3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00034a013

Reference yield:

: 146775-28-2
2-chloromethyl-5-phenylpyridine

: 155143-19-4
3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: 58 percent / Triton B / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: 144397-02-4
Ethyl [1-(4-chlorobenzyl)-3-t-butylthio-5-allyloxyindol-2-yl]carboxylate

: 155143-19-4
3-<<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>methoxy>propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 74 percent / Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 58 percent / Triton B / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013