(+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one

Base Information

• Chemical Name: (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one
• CAS No.: 77332-97-9
• Molecular Formula: C₁₄H₁₆O₅
• Molecular Weight: 264.278
• Mol file: 77332-97-9.mol

Synonyms:(+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one

Chemical Property of (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one

There total 3 articles about (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(4R,5S)-5-((Z)-3-[1,3]Dioxan-2-yl-propenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol (85612-85-7) → (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one (77332-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 40.8 g / pyridine / 3 h / 5 °C

2: 100 percent / hydrogen / platinum oxide / ethyl acetate / 6 h / Ambient temperature

3: 69.4 percent / ozone, oxygen / ethyl acetate / 5 h / -70 °C

4: 71.9 percent / trifluoroacetic acid / H₂O / 3.5 h / 0 °C

With pyridine; hydrogen; oxygen; ozone; trifluoroacetic acid; platinum(IV) oxide; In water; ethyl acetate;

DOI:10.1021/ja00349a053

Reference yield:

(+)-(4R-cis)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate (77332-94-6,77398-80-2) → (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one (77332-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / hydrogen / platinum oxide / ethyl acetate / 6 h / Ambient temperature

2: 69.4 percent / ozone, oxygen / ethyl acetate / 5 h / -70 °C

3: 71.9 percent / trifluoroacetic acid / H₂O / 3.5 h / 0 °C

With hydrogen; oxygen; ozone; trifluoroacetic acid; platinum(IV) oxide; In water; ethyl acetate;

DOI:10.1021/ja00349a053

Reference yield:

(+)-(4R-cis)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propyl>-1,3-dioxolane-4-methanol benzoate (77333-00-7,85648-04-0) → (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one (77332-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69.4 percent / ozone, oxygen / ethyl acetate / 5 h / -70 °C

2: 71.9 percent / trifluoroacetic acid / H₂O / 3.5 h / 0 °C

With oxygen; ozone; trifluoroacetic acid; In water; ethyl acetate;

DOI:10.1021/ja00349a053

upstream raw materials:

[(4R,5S)-5-((Z)-3-[1,3]Dioxan-2-yl-propenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol

(+)-(4R-cis)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propyl>-1,3-dioxolane-4-methanol benzoate

(+)-(4R-cis)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate

Downstream raw materials:

Benzoic acid (R)-2-methanesulfonyloxy-2-((S)-6-oxo-tetrahydro-pyran-2-yl)-ethyl ester

(5S,6S)-epoxy-10-formyl-(7E,9E)-decadienoic acid methyl ester

(-)-(S,S-trans)-3-(hydroxymethyl)oxiranebutanoic acid methyl ester

Leukotriene A₄ methyl ester