(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Base Information

Chemical Name:(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol
CAS No.:1224587-98-7
Molecular Formula:C₂₀H₃₂O₅Si
Molecular Weight:380.557
Hs Code.:

Synonyms:(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

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Technology Process of (3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

There total 1 articles about (3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 75467-36-6
5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-D-ribonolactone

: 591-51-5
phenyllithium

: 1224587-98-7
(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 6h;
DOI:10.1016/S0008-6215(00)90884-X

Reference yield: 68.0%

: 1224587-98-7
(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

: 115129-98-1
(R)-1,4-anhydro-5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-1-C-phenyl-D-ribitol

Guidance literature:: With dichloro-acetic acid; sodium cyanoborohydride; In various solvent(s); for 0.166667h; Ambient temperature;
DOI:10.1016/S0008-6215(00)90884-X

Reference yield:

: 1224587-98-7
(3aR,6R,6aR)-6-(tert-butyldimethylsilyloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

: 118436-96-7
1,5-anhydro-2,3-O-isopropylidene-1-C-phenyl-β-D-ribofuranose

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In acetonitrile; at -40 ℃; for 1h; Yield given;
DOI:10.1021/jo00264a020