(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

Base Information

Chemical Name:(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol
CAS No.:1432097-27-2
Molecular Formula:C₁₇H₁₆F₃NO₃
Molecular Weight:339.314
Hs Code.:

Synonyms:(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

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Chemical Property of (S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

Chemical Property:

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Technology Process of (S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

There total 4 articles about (S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.1%

: 1432048-81-1
{3,3-dimethoxy-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanone

: 1432097-27-2
(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

: 1432048-90-2
(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanone

Guidance literature:: With (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine; at 55 ℃; for 192h;

Reference yield:

: 49561-96-8
(4-trifluoromethoxy-phenyl)-acetonitrile

: 1432097-27-2
(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / dimethyl sulfoxide; water / 20 - 125 °C

2.1: methanol / 20 - 70 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.67 h / -78 °C

3.2: -78 - 20 °C

4.1: formic acid; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / 192 h / 55 °C

With methanol; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); n-butyllithium; formic acid; triethylamine; sodium t-butanolate; In diethyl ether; hexane; water; dimethyl sulfoxide;

Reference yield:

: 1432048-77-5
3,3-dimethoxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarboxamide

: 1432097-27-2
(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 - 70 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.67 h / -78 °C

2.2: -78 - 20 °C

3.1: formic acid; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / 192 h / 55 °C

With methanol; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); n-butyllithium; formic acid; triethylamine; In diethyl ether; hexane;