2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Chemical Name:2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
CAS No.:1352072-45-7
Molecular Formula:C₄₀H₄₅Cl₂NO₄Si
Molecular Weight:702.793
Hs Code.:

Synonyms:2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Technology Process of 2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

There total 4 articles about 2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1352076-63-1
C₄₁H₄₇Cl₂NO₂Si

: 1352072-45-7
2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; at 25 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm300354j

Reference yield:

: 1375799-11-3
(S)-ethyl 2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

: 1352072-45-7
2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere

3: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; lithium borohydride; ruthenium(III) trichloride hydrate; In tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300354j

Reference yield:

: 1352072-12-8
(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methylpiperidin-2-one

: 1352072-45-7
2-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 25 °C / Inert atmosphere

2.1: lithium borohydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere

4.1: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; lithium borohydride; ruthenium(III) trichloride hydrate; sodium hydride; In tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm300354j