Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:793684-26-1
Molecular Formula:C₂₆H₃₂N₇O₁₂PS
Molecular Weight:697.62
Hs Code.:

Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Synonyms:Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 7 articles about Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phosphoric acid 5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 3-hydroxy-5-(5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 793684-26-1
Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With acetic acid; at 20 ℃; for 6h;
DOI:10.1021/ja048492t

Reference yield:

: 108-98-5
thiophenol

: 793684-26-1
Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 26 percent / pyridine; ZnO / benzene / Heating

2.1: 74.2 percent / NH₃ / methanol / 20 °C

3.1: 4,5-dicyanoimidazole / dimethylformamide / 0.25 h

3.2: t-BuOOH / dimethylformamide; various solvent(s) / 0.42 h

4.1: NH₃ / methanol / 12 h / 20 °C

5.1: 180 mg / aq. AcOH / 6 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; ammonia; acetic acid; zinc(II) oxide; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja048492t

Reference yield:

: 6979-97-1,97834-40-7,142405-86-5
3',5'-diacetylthymidine

: 793684-26-1
Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-((5S,6R)-5-hydroxy-5-methyl-2,4-dioxo-6-phenylsulfanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 24.4 percent / Br₂; H₂O / 0.25 h / cooling

2.1: 26 percent / pyridine; ZnO / benzene / Heating

3.1: 74.2 percent / NH₃ / methanol / 20 °C

4.1: 4,5-dicyanoimidazole / dimethylformamide / 0.25 h

4.2: t-BuOOH / dimethylformamide; various solvent(s) / 0.42 h

5.1: NH₃ / methanol / 12 h / 20 °C

6.1: 180 mg / aq. AcOH / 6 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; ammonia; water; bromine; acetic acid; zinc(II) oxide; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja048492t