{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

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Chemical Name:{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester
CAS No.:209472-50-4
Molecular Formula:C₃₂H₅₈N₂O₄Si
Molecular Weight:562.909
Hs Code.:

Synonyms:{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

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Chemical Property of {4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

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Technology Process of {4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

There total 13 articles about {4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 204513-82-6
{4-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

: 209472-50-4
{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; under 1551.4 Torr;
DOI:10.1021/jm980001q

Reference yield:

: 79677-60-4
(S)-N-benzyloxycarbonyl-3-(4-hydroxy-3-iodophenyl)alanine methyl ester

: 209472-50-4
{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Heating

2: 96 percent / Et₃N, (Ph₃)2PPdCl₂, CuI / acetonitrile / 4 h / Ambient temperature

3: H₂, AcOH / 5percent Pd/C / methanol / 16 h / 2585.7 Torr

4: N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

5: 0.75 g / triphenoxymethylphosphonium iodide / acetonitrile / 3 h / Ambient temperature

6: 0.58 g / NaN₃ / dimethylformamide / 3 h / 70 °C

7: triphenylphosphine, H₂O / tetrahydrofuran / 3 h / 20 - 60 °C

8: CH₂Cl₂ / 1.5 h / Ambient temperature

9: 0.4 g / 1 M LiOH / tetrahydrofuran / 1.5 h / Ambient temperature

10: 0.3 g / BH₃ / tetrahydrofuran / 2 h / -5 - 10 °C

11: 47 percent / imidazole, N-methylmorpholine / acetonitrile / 2.5 h / 60 °C

12: H₂ / 10percent Pd/C / ethanol / 1.5 h / 1551.4 Torr

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; copper(l) iodide; sodium azide; (Ph₃)2PPdCl₂; borane; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; water; hydrogen; acetic acid; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980001q

Reference yield:

: 79677-58-0,122908-62-7
2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride

: 209472-50-4
{4-[5-[(S)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) N-methylmorpholine / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, from 10 deg C to RT, 3 h

2: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Heating

3: 96 percent / Et₃N, (Ph₃)2PPdCl₂, CuI / acetonitrile / 4 h / Ambient temperature

4: H₂, AcOH / 5percent Pd/C / methanol / 16 h / 2585.7 Torr

5: N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

6: 0.75 g / triphenoxymethylphosphonium iodide / acetonitrile / 3 h / Ambient temperature

7: 0.58 g / NaN₃ / dimethylformamide / 3 h / 70 °C

8: triphenylphosphine, H₂O / tetrahydrofuran / 3 h / 20 - 60 °C

9: CH₂Cl₂ / 1.5 h / Ambient temperature

10: 0.4 g / 1 M LiOH / tetrahydrofuran / 1.5 h / Ambient temperature

11: 0.3 g / BH₃ / tetrahydrofuran / 2 h / -5 - 10 °C

12: 47 percent / imidazole, N-methylmorpholine / acetonitrile / 2.5 h / 60 °C

13: H₂ / 10percent Pd/C / ethanol / 1.5 h / 1551.4 Torr

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; copper(l) iodide; sodium azide; (Ph₃)2PPdCl₂; borane; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; water; hydrogen; acetic acid; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980001q