(R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate

Base Information

• Chemical Name: (R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate
• CAS No.: 1443760-79-9
• Molecular Formula: C₂₂H₃₇N₃O₄
• Molecular Weight: 407.553
• Mol file: 1443760-79-9.mol

Synonyms:(R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate

Chemical Property of (R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate

There total 1 articles about (R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

Cyclohexyl isocyanide (931-53-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + Glutaraldehyde (111-30-8,29257-65-6,79215-57-9) → (R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate (1443760-79-9)

Guidance literature:

glycine ethyl ester hydrochloride; Glutaraldehyde; With citric acid; In methanol; water; at 20 ℃; for 0.05h;

Cyclohexyl isocyanide; In methanol; water; at 20 ℃; for 48h;

DOI:10.1002/ejoc.201201316

Reference yield: 84.0%

(R,S)-methyl 2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetate (1443760-79-9) → (R,S)-2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetic acid (1443760-80-2)

Guidance literature:

With potassium hydroxide; In methanol; water; at 20 ℃; for 12h;

DOI:10.1002/ejoc.201201316

upstream raw materials:

Cyclohexyl isocyanide

glycine ethyl ester hydrochloride

Glutaraldehyde

Downstream raw materials:

(R,S)-2,6-bis(cyclohexylcarbamoyl)piperidin-1-ylacetic acid