Technology Process of (3R,4R)-5-azido-4-fluoro-3-benzyloxy-pent-1-ene
There total 4 articles about (3R,4R)-5-azido-4-fluoro-3-benzyloxy-pent-1-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; diethylamino-sulfur trifluoride;
In
benzene;
at -78 - 20 ℃;
DOI:10.1021/cb5003416
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Cumene hydroperoxide / titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 48 h / -35 °C / Molecular sieve
2: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / -15 - 20 °C / Inert atmosphere
3: sodium azide; ammonium chloride / water; methanol / 96 h
4: diethylamino-sulfur trifluoride; pyridine / benzene / 54 h / -10 - 20 °C
With
pyridine; sodium azide; diethylamino-sulfur trifluoride; Cumene hydroperoxide; sodium hydride; ammonium chloride;
titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; mineral oil; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / -15 - 20 °C / Inert atmosphere
2: sodium azide; ammonium chloride / water; methanol / 96 h
3: diethylamino-sulfur trifluoride; pyridine / benzene / 54 h / -10 - 20 °C
With
pyridine; sodium azide; diethylamino-sulfur trifluoride; sodium hydride; ammonium chloride;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; methanol; water; mineral oil; benzene;
