1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

Base Information

Chemical Name:1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol
CAS No.:212686-72-1
Molecular Formula:C₃₂H₃₈O₅Si
Molecular Weight:530.736
Hs Code.:

Synonyms:1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

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Chemical Property of 1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

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Technology Process of 1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

There total 1 articles about 1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 96690-02-7
5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 4440-01-1
lithium phenylacetylide

: 212686-72-1
1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1039/a802228c

Reference yield:

: 212686-72-1
1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

: 212686-90-3
(R)-2-Methoxymethoxy-2-[(4R,5S)-5-((R)-1-methoxymethoxy-3-phenyl-prop-2-ynyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: i-PrNEt₂ / CH₂Cl₂ / Ambient temperature

2: TBAF / tetrahydrofuran / Ambient temperature

With N,N-diethyl-N-isopropylamine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/a802228c

Reference yield:

: 212686-72-1
1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-phenyl-propynol

: 212686-75-4
(R)-2-Methoxymethoxy-2-[(4R,5S)-5-((S)-1-methoxymethoxy-3-phenyl-prop-2-ynyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: i-PrNEt₂ / CH₂Cl₂ / Ambient temperature

2: 92 percent / TBAF / tetrahydrofuran / Ambient temperature

With N,N-diethyl-N-isopropylamine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/a802228c