1-<(benzyloxy)methyl>-4-diiodoimidazole

Base Information

• Chemical Name: 1-<(benzyloxy)methyl>-4-diiodoimidazole
• CAS No.: 134420-49-8
• Molecular Formula: C₁₁H₁₁IN₂O
• Molecular Weight: 314.126
• Mol file: 134420-49-8.mol

Synonyms:1-<(benzyloxy)methyl>-4-diiodoimidazole

Chemical Property of 1-<(benzyloxy)methyl>-4-diiodoimidazole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-<(benzyloxy)methyl>-4-diiodoimidazole

There total 6 articles about 1-<(benzyloxy)methyl>-4-diiodoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-benzyloxymethyl-4,5-diiodo-1H-imidazole (134420-43-2) → 1-<(benzyloxy)methyl>-4-diiodoimidazole (134420-49-8)

Guidance literature:

With n-butyllithium; 1.) THF, hexanes, -78 degC, 30 min, 2.) warm to room temp. within 20 min;

DOI:10.1021/jo00013a042

Reference yield: 75.0%

1-benzyloxymethyl-4,5-diiodo-1H-imidazole (134420-43-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-<(benzyloxy)methyl>-4-diiodoimidazole (134420-49-8) + 1-(benzyloxy)methyl-5-formyl-4-iodoimidazole (134420-45-4) + 1-<(benzyloxy)methyl>-4,5-diiodoimidazole-2-carboxaldehyde (134420-48-7)

Guidance literature:

With n-butyllithium; Product distribution; other reaction times;

DOI:10.1021/jo00013a042

Reference yield: 68.0%

1-benzyloxymethyl-4,5-diiodo-1H-imidazole (134420-43-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-<(benzyloxy)methyl>-4-diiodoimidazole (134420-49-8) + 1-<(benzyloxy)methyl>-4-iodoimidazole-2-carboxaldehyde (134420-46-5) + 1-<(benzyloxy)methyl>-4,5-diiodoimidazole-2-carboxaldehyde (134420-48-7)

Guidance literature:

With n-butyllithium; Yields of byproduct given; 1.) THF, hexanes, -78 degC, 45 min, 2.) warm to room temp. within 20 min;

DOI:10.1021/jo00013a042

upstream raw materials:

1-benzyloxymethyl-4,5-diiodo-1H-imidazole

N,N-dimethyl-formamide

Benzyloxymethyl chloride

1-<(Benzyloxy)methyl>-2,4,5-triiodoimidazole

Downstream raw materials:

1-(Benzyloxymethyl-1H-imidazol-4-yl)-1-(6,7-dimethoxy-2-naphthyl)-2-methyl-1-propanol

1-<(benzyloxy)methyl>-4-iodoimidazole-2-carboxaldehyde