(S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester

Base Information

• Chemical Name: (S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester
• CAS No.: 364802-19-7
• Molecular Formula: C₂₆H₂₄N₄O₃
• Molecular Weight: 440.502

Synonyms:(S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester

Chemical Property of (S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester

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Technology Process of (S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester

There total 1 articles about (S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-2-{(2-Amino-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester → (S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester (364802-19-7)

Guidance literature:

(S)-2-{(2-Amino-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester; With hydrogenchloride; sodium nitrite; In acetic acid; at 0 ℃; for 0.5h;

With sodium azide; In diethyl ether; acetic acid; for 1h;

DOI:10.1016/S0957-4166(01)00190-2

Reference yield: 92.0%

(S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester (364802-19-7) → 2-benzyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one (946533-92-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 4h; Heating;

DOI:10.1016/j.tetasy.2007.05.015

Reference yield: 47.0%

(S)-2-{(2-Azido-benzyl)-[(E)-(3-phenyl-acryloyl)]-amino}-propionic acid benzyl ester (364802-19-7) → 2-(2-oxo-1-phenyl-1a,2-dihydro-1H,4H-3,8b-diaza-benzo[a]cyclopropa[c]cyclohepten-3-yl)-propionic acid benzyl ester + 2-(2-oxo-1-phenyl-1a,2-dihydro-1H,4H-3,8b-diaza-benzo[a]cyclopropa[c]cyclohepten-3-yl)-propionic acid benzyl ester

Guidance literature:

With triethylamine; In toluene; for 6.5h; Heating;

DOI:10.1016/S0957-4166(01)00190-2

Downstream raw materials:

2-benzyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one

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