Technology Process of (2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane
There total 15 articles about (2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
DOI:10.1016/S0040-4039(02)01865-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / CH2Cl2 / 0.5 h / -10 °C
2.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: tetrahydrofuran; hexane / 18 h / -78 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.03.035
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 60 percent / Candida antarctica lipase B; molecular sieves 3 Angstroem / diethyl ether / 2 h / 20 °C
2.1: 94 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
3.1: 82 percent / sodium borohydride / dimethylsulfoxide / 20 h / 115 °C
4.1: 80 percent / sodium hydride / tetrahydrofuran / 20 h / 20 °C
5.1: triethylamine / CH2Cl2 / 0.5 h / -10 °C
6.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
6.2: tetrahydrofuran; hexane / 18 h / -78 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; Candida antarctica lipase B; sodium tetrahydroborate; n-butyllithium; 3 A molecular sieve; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2006.03.035
