(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

Base Information

Chemical Name:(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane
CAS No.:479353-41-8
Molecular Formula:C₄₂H₅₄O₄S
Molecular Weight:654.954
Hs Code.:

Synonyms:(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

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Chemical Property of (2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

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Technology Process of (2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

There total 15 articles about (2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 56881-53-9
(E,E)-farnesyl phenylsulfone

: 479353-40-7
(R)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate

: 479353-41-8
(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1016/S0040-4039(02)01865-8

Reference yield:

: 188416-16-2
(R)-(+)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol

: 479353-41-8
(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

2.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: tetrahydrofuran; hexane / 18 h / -78 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.03.035

Reference yield:

: 105857-77-0
2,2-Bis-hydroxymethyl-5,7,8-trimethyl-chroman-6-ol

: 479353-41-8
(2R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyl-2-(phenylsulfonyl)trideca-3,7,11-trien-1-yl)chromane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / Candida antarctica lipase B; molecular sieves 3 Angstroem / diethyl ether / 2 h / 20 °C

2.1: 94 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

3.1: 82 percent / sodium borohydride / dimethylsulfoxide / 20 h / 115 °C

4.1: 80 percent / sodium hydride / tetrahydrofuran / 20 h / 20 °C

5.1: triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

6.1: hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: tetrahydrofuran; hexane / 18 h / -78 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; Candida antarctica lipase B; sodium tetrahydroborate; n-butyllithium; 3 A molecular sieve; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2006.03.035