10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Base Information

Chemical Name:10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one
CAS No.:1380647-36-8
Molecular Formula:C₂₀H₂₀FN₅O₃
Molecular Weight:397.409
Hs Code.:

Synonyms:10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

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Chemical Property of 10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

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Technology Process of 10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

There total 4 articles about 10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1380647-35-7
benzyl (3-(benzyloxy)-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

: 1380647-36-8
10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1188429-06-2
ethyl 10-(((benzyloxy)carbonyl)amino)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a] azepine-2-carboxylate

: 1380647-36-8
10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / ethanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

4: hydrazine / dichloromethane / 16 h / 20 °C

5: triethylamine / dichloromethane / 4 h / 0 - 20 °C

6: N-ethyl-N,N-diisopropylamine; triphenylphosphine; hexachloroethane / acetonitrile / 16 h

7: hydrogen bromide; acetic acid / dichloromethane / 16 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; hexachloroethane; water; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1380647-28-8
3-(benzyloxy)-10-(((benzyloxy)carbonyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid

: 1380647-36-8
10-amino-2-(5-(4-fluorobenzyl)-1,3,4-oxadiazol-2-yl)-3-hydroxy-7,8,9,10-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

2: hydrazine / dichloromethane / 16 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; triphenylphosphine; hexachloroethane / acetonitrile / 16 h

5: hydrogen bromide; acetic acid / dichloromethane / 16 h / 20 °C

With oxalyl dichloride; hexachloroethane; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;