tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate

Base Information

• Chemical Name: tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate
• CAS No.: 1023328-37-1
• Molecular Formula: C₄₀H₅₀F₃N₃O₆Si
• Molecular Weight: 753.934
• Mol file: 1023328-37-1.mol

Synonyms:tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate

Chemical Property of tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate

There total 1 articles about tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tert-butyl 4-[(1S,2R,5S)-5-(tert-butyldimethylsilanyloxy)-5-(4-fluorophenyl)-1-(4-fluorophenylamino)-2-((S)-4-phenyloxazolidin-2-one-3-carbonyl)pentyl]-3-fluorophenyl piperazine-1,4-dicarboxylate (1023328-36-0) → tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate (1023328-37-1)

Guidance literature:

tert-butyl 4-[(1S,2R,5S)-5-(tert-butyldimethylsilanyloxy)-5-(4-fluorophenyl)-1-(4-fluorophenylamino)-2-((S)-4-phenyloxazolidin-2-one-3-carbonyl)pentyl]-3-fluorophenyl piperazine-1,4-dicarboxylate; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; at 20 ℃; for 0.5h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene; at 0 - 20 ℃;

Reference yield: 68.0%

tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate (1023328-37-1) → 3-fluoro-4-{(2S,3R)-1-(4-fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenyl piperazine-1-carboxylate

Guidance literature:

tert-butyl 4-[(2S,3R)-3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluoro-phenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1,4-dicarboxylate; With sulfuric acid; In tetrahydrofuran; at 50 ℃;

With ammonia; In tetrahydrofuran; methanol; dichloromethane; at 5 ℃;

upstream raw materials:

tert-butyl 4-[(1S,2R,5S)-5-(tert-butyldimethylsilanyloxy)-5-(4-fluorophenyl)-1-(4-fluorophenylamino)-2-((S)-4-phenyloxazolidin-2-one-3-carbonyl)pentyl]-3-fluorophenyl piperazine-1,4-dicarboxylate