4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

Base Information

Chemical Name:4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone
CAS No.:936318-19-3
Molecular Formula:C₁₅H₂₀O₄
Molecular Weight:264.321
Hs Code.:

Synonyms:4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

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Chemical Property of 4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

Chemical Property:

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Technology Process of 4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

There total 6 articles about 4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 936318-18-2
4-(2,5-dimethoxybenzyl)-5,5-dimethyltetrahydrofuran-2-ol

: 936318-19-3
4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1080/00397910601163919

Reference yield:

: 15804-86-1,24393-64-4
(2E)-ethyl 3-(2,5-dimethoxyphenyl)propenoate

: 936318-19-3
4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / 760 Torr

2.1: LDA / tetrahydrofuran; hexane / 0.75 h / -70 °C

2.2: 81 percent / tetrahydrofuran; hexane / 10 h / 20 °C

3.1: 88 percent / diethyl ether / 0 - 20 °C

4.1: O₃; NaHCO₃ / methanol; CH₂Cl₂ / 0.01 h / -70 °C

4.2: 99 percent / Me₂S / methanol; CH₂Cl₂ / 10 h / 20 °C

5.1: 93 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

With hydrogen; silica gel; sodium hydrogencarbonate; ozone; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 3.1: Grignard reaction;
DOI:10.1080/00397910601163919

Reference yield:

: 93-02-7
2,5-dimethoxybenzaldehyde

: 936318-19-3
4-(2,5-dimethoxybenzyl)-5,5-dimethyldihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: 100 percent / tetrahydrofuran / 6 h / 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / 760 Torr

3.1: LDA / tetrahydrofuran; hexane / 0.75 h / -70 °C

3.2: 81 percent / tetrahydrofuran; hexane / 10 h / 20 °C

4.1: 88 percent / diethyl ether / 0 - 20 °C

5.1: O₃; NaHCO₃ / methanol; CH₂Cl₂ / 0.01 h / -70 °C

5.2: 99 percent / Me₂S / methanol; CH₂Cl₂ / 10 h / 20 °C

6.1: 93 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

With hydrogen; silica gel; sodium hydride; sodium hydrogencarbonate; ozone; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 1.2: Horner-Wadsworth-Emmons reaction / 4.1: Grignard reaction;
DOI:10.1080/00397910601163919