1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

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Chemical Name:1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea
CAS No.:1429307-38-9
Molecular Formula:C₂₉H₃₂FN₇O₂S
Molecular Weight:561.683
Hs Code.:

Synonyms:1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

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Chemical Property of 1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

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Technology Process of 1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

There total 5 articles about 1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 109-01-3
1-methyl-piperazine

: 1429307-79-8
1-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(1-methylazetidin-3-yl)urea

: 1429307-38-9
1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

Guidance literature:: With sodium cyanoborohydride; acetic acid; at 20 - 55 ℃; for 4.75h;

Reference yield:

: 1429307-78-7
1-(4-(2-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(1-methylazetidin-3-yl)urea

: 1429307-38-9
1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; tetrahydrofuran / 0.5 h

2: acetic acid; sodium cyanoborohydride / 4.75 h / 20 - 55 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; water;

Reference yield:

: 1123837-62-6
4-(2-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline

: 1429307-38-9
1-(3-fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(1-methylazetidin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 0.25 h

1.2: 4 h / 110 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h

3.1: sodium cyanoborohydride / methanol; water / 0.25 h

4.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h

5.1: acetic acid; sodium cyanoborohydride / 4.75 h / 20 - 55 °C

With pyridine; hydrogenchloride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;