2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

Base Information

Chemical Name:2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one
CAS No.:177499-62-6
Molecular Formula:C₂₄H₂₃N₃O
Molecular Weight:369.466
Hs Code.:

Synonyms:2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

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Chemical Property of 2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

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Technology Process of 2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

There total 4 articles about 2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 177499-60-4
N-[3-Cyano-1-((R)-1-phenyl-ethyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]-benzamide

: 177499-62-6
2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

Guidance literature:: With N,N-dimethyl-cyclohexanamine; water; phosphorus pentoxide; at 190 - 200 ℃; for 4h;
DOI:10.1021/jm960011w

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 177499-62-6
2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) p-toluenesulfonic acid, 2.) piperidine / 1.) cyclohexane, reflux, 2.) cyclohexane, reflux

2: 77 percent / pyridine / CH₂Cl₂ / 1 h

3: 44 percent / P₂O₅, N,N-dimethylcyclohexylamine, H₂O / 4 h / 190 - 200 °C

With piperidine; pyridine; N,N-dimethyl-cyclohexanamine; water; phosphorus pentoxide; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/jm960011w

Reference yield:

: 152518-24-6
(R)-2-amino-4,5,6,7-tetrahydro-1-(1-phenylethyl)-1H-indole-3-carbonitrile

: 177499-62-6
2-Phenyl-9-((R)-1-phenyl-ethyl)-3,5,6,7,8,9-hexahydro-pyrimido[4,5-b]indol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / pyridine / CH₂Cl₂ / 1 h

2: 44 percent / P₂O₅, N,N-dimethylcyclohexylamine, H₂O / 4 h / 190 - 200 °C

With pyridine; N,N-dimethyl-cyclohexanamine; water; phosphorus pentoxide; In dichloromethane;
DOI:10.1021/jm960011w