2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide

Base Information

• Chemical Name: 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide
• CAS No.: 1612898-56-2
• Molecular Formula: C₁₇H₁₅ClN₄O₂S
• Molecular Weight: 374.851
• Mol file: 1612898-56-2.mol

Synonyms:2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide

Chemical Property of 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide

There total 4 articles about 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate → 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (1612898-56-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2015.02.025

Reference yield:

3-benzyl-6-chloro-2-mercaptoquinazolin-4(3H)-one (23070-25-9) → 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (1612898-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: hydrazine hydrate / ethanol / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/j.bmcl.2015.02.025

Reference yield:

Benzyl isothiocyanate (622-78-6) → 2-((3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (1612898-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / Reflux

2: potassium carbonate / acetone / Reflux

3: hydrazine hydrate / ethanol / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; acetone;

DOI:10.1016/j.bmcl.2015.02.025

upstream raw materials:

3-benzyl-6-chloro-2-mercaptoquinazolin-4(3H)-one

5-chloroanthranilic acid

Benzyl isothiocyanate

Downstream raw materials:

N'-acetyl-2-(3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetohydrazide

N'-(2-(3-benzyl-6-chloro-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetyl)-3-phenylpropanehydrazide