3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine

Base Information

• Chemical Name: 3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine
• CAS No.: 6654-69-9
• Molecular Formula: C12H13N3
• Molecular Weight: 199.255
• European Community (EC) Number: 653-177-7
• NSC Number: 238939
• DSSTox Substance ID: DTXSID90985150
• Nikkaji Number: J3.309.607K
• Wikidata: Q82972616
• Mol file: 6654-69-9.mol

Synonyms:3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine;6654-69-9;N(c1ncccc1C)c2ncccc2C;Bis(3-methyl-2-pyridyl)amine;SCHEMBL15368480;DTXSID90985150;NSC238939;AKOS024323815;NSC-238939;3-methyl-N-(3-methyl-2-pyridinyl)-2-pyridinamine

Chemical Property of 3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 357°Cat760mmHg
• Flash Point: 169.7°C
• Density: 1.1g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 199.110947427
• Heavy Atom Count: 15
• Complexity: 175

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)NC2=C(C=CC=N2)C

Technology Process of 3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine

There total 2 articles about 3-methyl-N-(3-methylpyridin-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-methylpyridin-2-ylamine (1603-40-3) + 2-bromo-3-picoline (3430-17-9) → 3,3’-dimethyl-2,2’-dipyridylamine (6654-69-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; In toluene; at 110 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ic501230m

Reference yield:

2 chloro-3-methylpyridine (18368-76-8) → 3-methylpyridin-2-ylamine (1603-40-3) + 3,3’-dimethyl-2,2’-dipyridylamine (6654-69-9)

Guidance literature:

With diphenyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; diphenyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C₅₀H₅₈NO₄PPdS; C₅₀H₅₈NO₄PPdS; ammonia; sodium t-butanolate; In 1,4-dioxane; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol401612c

Reference yield: 98.0%

potassium hexafluorophosphate (17084-13-8) + chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (578743-87-0) + 3,3’-dimethyl-2,2’-dipyridylamine (6654-69-9) → (1,3-bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene) (3,3’-dimethyl-2,2’-dipyridylamine) copper hexafluorophosphate

Guidance literature:

chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); 3,3’-dimethyl-2,2’-dipyridylamine; In ethanol; for 1h; Inert atmosphere; Schlenk technique; Reflux;

potassium hexafluorophosphate; In ethanol; water; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ic501230m

upstream raw materials:

2 chloro-3-methylpyridine

3-methylpyridin-2-ylamine

2-bromo-3-picoline