(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Base Information

Chemical Name:(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester
CAS No.:130517-73-6
Molecular Formula:C₂₇H₄₇NO₄Si
Molecular Weight:477.76
Hs Code.:

(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Synonyms:(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Suppliers and Price of (Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

There total 7 articles about (Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 130517-72-5
(E)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

: 130517-73-6
(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Guidance literature:: In acetone; at -10 ℃; for 2.5h; Irradiation;
DOI:10.1248/cpb.38.1784

Reference yield:

: 148766-02-3
(S)-2-((1R,2S,6R)-2-Hydroxymethyl-6-methyl-cyclohexyl)-propionitrile

: 130517-73-6
(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Swern oxidation

2: 1.) lithium diisopropylamide / 1.) THF, -100 deg C, 15 min, 2.) 15 min

3: 4-dimethylaminopyridine, pyridine / 24 h / Ambient temperature

4: DBU / 20 h / Ambient temperature

5: 50 percent / acetone / 2.5 h / -10 °C / Irradiation

With pyridine; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In acetone;
DOI:10.1248/cpb.38.1784

Reference yield:

: 130517-70-3
(S)-2-((1R,2S,6R)-2-Formyl-6-methyl-cyclohexyl)-propionitrile

: 130517-73-6
(Z)-2-[(2R,3R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(1S,2S,3R)-2-((S)-cyano-methyl-methyl)-3-methyl-cyclohexyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium diisopropylamide / 1.) THF, -100 deg C, 15 min, 2.) 15 min

2: 4-dimethylaminopyridine, pyridine / 24 h / Ambient temperature

3: DBU / 20 h / Ambient temperature

4: 50 percent / acetone / 2.5 h / -10 °C / Irradiation

With pyridine; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In acetone;
DOI:10.1248/cpb.38.1784