allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1248520-96-8
Molecular Formula:C₂₄H₂₀F₃N₃O₃S
Molecular Weight:487.502
Hs Code.:

Synonyms:allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 8 articles about allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1118-84-9
allyl acetoacetate

: 1161921-97-6
4‐formyl‐3‐(methylthio)benzonitrile

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 1248520-96-8
allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With triethyl phosphate; phosphorus pentoxide; In tert-butyl methyl ether; at 50 ℃; Inert atmosphere; Reflux;

Reference yield: 19.0%

: 1118-84-9
allyl acetoacetate

: 1161921-93-2
4-formyl-3-(methylsulfonyl)benzonitrile

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 1248520-96-8
allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With triethyl phosphate; In tert-butyl methyl ether; at 50 ℃; Inert atmosphere; Reflux;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1248520-96-8
allyl 4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 20 - 175 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

3: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

4: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5: triethyl phosphate / tert-butyl methyl ether / 50 °C / Inert atmosphere; Reflux

With sodium periodate; triethyl phosphate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;